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Authors
Affiliations
1 Department of Chemistry, Nizam College, OU, Basheerbagh, Hyderabad-500001, Telangana, IN
2 Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Telangana, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 3 (2017), Pagination: 291-296
Abstract
The Co(II) metal (M) complex of 2,4-dichloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide (L) was synthesized and characterized by elemental analysis, molar conductance, magnetic moment measurements, LC-MS, IR, TGA and UV spectral studies. Irving-Rossetti titration method was employed to determine the acid dissociation constant of ligand and the stability constant of Co(II) complex in 70% (v/v) DMF-water medium at 0.1 M KNO3 ionic strength and 303K temperature. The spectroanalytical data indicate the composition of the complexes to be 1:2 (ML2) with octahedral geometry. The ligand and the complex were screened for their antibacterial activity against Gram positive and Gram negative bacteria using agar well diffusion method.
Keywords
Pyridoxal, Schiff Base, Complex, Stability Constant, Antibacterial Activity.
